Bio x4 Review 2017: Ingredients, Results, Side Effects, Where To Buy It & Best Alternative

We do not recommend Bio x4. If you want to skip this review and see the best alternative click here. Otherwise keep reading!

Bio X4 is made by a company called Nucific. It is a digestive enzyme blend that claims to use the benefits of probiotics to help lose weight quickly, as well as manage your digestive system better.

I’m going to look at Nucifix Bio x4 reviews around the Internet, plus take a look at what users say, in addition to my own personal testing, to try to get an answer the question: does Bio x4 work.


biox4 photo

A great way to understand if the purported benefits of any supplements stack up is to have a look at what is in them. So let’s take a look at the three main Bio x4 ingredients to see exactly what they do:

  1. Digestive enzymes

According to the company who make it, Nucifix Bio x4 “contains enzymes that maximize the amount of nutrients you absorb out of everything you eat.” These enzymes are Amylase, which is reputed to break down sugars, Lipase, which may break down fats, and Bromelain, which may help to break down proteins.

  1. Caralluma fimbriata

Caralluma fimbriata has in many studies been shown to suppress appetite. There is some evidence from the studies that that is indeed the case, however results were often very minor.

  1. EGCG

This is naturally found in green tea. It is reputed to boost the body’s natural ability to burn fat. Some studies have listed great results, however these are usually disputed when the details are looked at.

Side Effects

It does appear that Nucifix Bio x4 side effects, although common, are pretty minor. They are generally digestive side effects that most people will suffer anyway at some stage:

  • Excessive intestinal gas
  • Bloating of the stomach
  • Minor cramps in the abdominal region
  • Nausea but not vomiting
  • Diarrhea
  • Issues with urination frequency and pain
  • Joint pain

Now obviously, anything which says it might cause you pain is a cause for concern. However, looking around the Internet, many seemingly genuine reviews appear to say that this product eases those symptoms rather than causing them.

Certainly in my own testing of this product to see if I can replicate the positive Bio x4 results, I have experienced only a couple of the symptoms in a very minor manner.

What Results Can You Expect?

The claimed results of using Bio x4 are:

  • Improved bowel regularity
  • Better digestion
  • Improved immune system function
  • Positive effect on weight management

These are of course impressive statements, and the basic rationale is that put together they support your digestive system to be more efficient and potentially to “supercharge” it in addition to suppressing appetite.

There is some clinical evidence that the ingredients do achieve what they say. For example, users do routinely report a feeling of being less hungry.

In terms of results, I don’t think you can expect a miracle because otherwise this product would cost a fortune and be recommended by doctors all over the world. The truth is you can’t buy Bio x4 in stores, which says a lot about the lack of confidence in this product.

Is It A Scam?

No I don’t think that a Bio x4 scam is the purpose behind selling it. Nucific make some claims around this product that sound almost too good to be true, but taken individually, the ingredients do give minor digestive benefits with some scientific evidence to back it up.

The problem comes in the marketing assumption that combining these active ingredients together forms some sort of “miracle pill” that will solve all your food problems. I think the company gently allude to this, and then excited users have talked it up in a way that is beyond the truth.

Nucifix Bio x4 Reviews From Users


Whenever I want to get the lowdown on how effective a diet and digestive supplement is, I always check product testimonials online. Wesbites like has a lot of Bio x4 real people reviews. Take a look below.

First a typical positive review:

“I have been using BIO X4 for over a month and have lost 11 pounds. I have tried a few other diets and have ended up on the weight roller coaster. I like that I can still enjoy the foods I love and not have to make two different meals for my family. I have noticed that I now eat less and feel full longer. I do not have the cravings for candy, chips, or ice cream. I find myself instead going for the fruits and veggies without thinking. Thank you.”

There is more 5-star customer feedbacks like this:

“I have been using BIO X4 for three months. I have lost over 35 pounds. I sleep better, eat better and my stomach problems have dissipated. I can’t believe how much energy I have. I will continue to use BIO X4. I no longer take prescription medications for my past stomach problems, fibromyalgia, diabetes or pain management. The video inspired me to change my entire way of eating and living, at age 49.”

But I have found also a negative reviews.

Hi, I’ve been taking this now for two weeks and I wake up every day with a headache and feel worse than the previous day. On top of the headache, I’m running to the bathroom constantly and have a lot of bloating and stomach pain. If this is supposed to correct my digestive system, it doesn’t seem to be working.
It’s giving more pain than pleasure and feeling the way I do makes me not want to go anywhere for fear I will have an accident. My digestive system and head are not happy campers.”

The good thing is, company always answer to these bad reviews and try to find a solution. In this case Nucific offered a refund. Awesome!

Pros & Cons

As my own results have been quite subdued, and trying to keep a dose of reality around claims made about this product, I’m stating the pros of Bio x4 as:

  • Natural ingredients, with no gluten or fillers
  • 90 day money back guarantee
  • Third-party lab tested
  • The company is transparent about who runs it
  • Ingredients individually do offer potential minor stated benefits

And in terms of the cons of Bio x4:

  • You cannot buy in retail stores
  • There are side effects although these are mostly minor
  • There is no evidence that the combination of ingredients offers any additional benefits
  • Some product benefits are apparently exaggerated

Where To Buy It

If you are wondering where to buy Bio x4, then the first point to make is that this is not available in physical stores. You can’t buy it unless you order online.

The best place to buy it is official website. But you can get it also from specialist online retailers like a GNC.

I’ve had a quick look and if you are interested in a purchase, you can get a Bio x4 coupon on some of the larger coupon websites, although I haven’t tested those and they change frequently.

Notice: You can buy this product on Amazon too. But these sellers are not authorized to reselling and can’t offer you a 90-day money back guarantee.

How Much Does It Cost
  • 6 bottles (180 days supply): $487.08 – SAVE %18
  • 3 bottles (90 days supply): $261.36 – SAVE %12
  • 1 bottle (30 days supply): $99.00
Final Verdict

In conclusion, my review of Nucifix Bio x4 has to conclude that the stated benefits of this dietary supplement are open to interpretation and challenge.

Yes the active ingredients do appear to offer some benefits, but I’m not convinced that just buying these ingredients separately at a lower price won’t have exactly the same effect, and will certainly affect your bank balance less.

I tried it myself and over the time I tried it I did feel that my digestive system was less problematic than before, but there was no sign of weight loss or a lessening of appetite.

Recommended Alternative

phen375 bottles

An alternative supplement I would suggest is Phen375. It also has a natural list of ingredients, but these are radically different to those contained in Bio x4.

In addition, even if you haven’t tried Phen375, a look around the Internet will tell you that a lot of people have and it does seem to have a much higher percentage of positive fans than a lot of these dietary supplements.

Phen375 is sold as a “fat burner”, so if that reason you have been considering Bio x4, then I strongly suggest that you spend your money on giving Phen375 ago first.

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12 thoughts on “Bio x4 Review 2017: Ingredients, Results, Side Effects, Where To Buy It & Best Alternative”

  1. Richard says:

    I have found this product to be beneficial. My digestive system is more efficient then before, and I do have some loss of appetite. Two weeks into using it, I give it a thumbs up!

  2. Kelly Williams says:

    I silly act disease and I wake up everyday just begging for energy cannot seem to eat anything that doesn’t make me feel bad my medicine that I take makes me feel bad and I started taking bio X4 and I just seem to have a little bit more energy I can’t digest food better and I’m not just eating anything I want I’m eating what I need to maintain a healthy diet I’m so happy I can’t say it enough if dr. Lee called me right now I would tell her thank you thank you thank you I am a very sick person but I’m not anymore thank you and I even had breast cancer and I can say that everything they gave me through all of the medicines and stuff this has made me feel better than I could ever expect better than I ever expected

  3. Judy kramps says:

    I just saw a video on Facebook about BIO-X4. I thought I might try it, but the video never showed me how to do that . Plus-and this would be a determining factor of buying the product. The cost was 49.99 and the price would always be $49.99. So please let me know if I can buy it for that price now and in the future. Judy L K

    1. Naomi Benson says:

      Hi there Judy,

      Naomi here with Nucific. I am happy to hear that you are interested in trying our top selling product, BIO X4. I would be more than happy to assist you with your purchase. Please send me an email at so that I can further assist you with this. I look forward to hearing from you Judy. Thank you.

  4. Lesley says:

    This product caused me a lot of discomfort and the bloating was excessive. The bloating is what curbed my appetite and not what was in the product. It turned my system into a blocked and semi constipated state, not exactly what one of their claims is. It made me uncomfortable and feel ill and I had to be off of it at least a week before my system returned to normal. I messaged Dr. Amy Lee about it for feedback and the response I got, and I am not unaware that she is most likely NOT the one responding, was to call customer service about my next step. It’s been over 90 days so they are going in the trash.

    1. Naomi Benson says:

      Hi there Lesley,

      Naomi here with Nucific. I am sorry to hear that you did not have a good experience while taking BIO X4. While many of our customers see incredible results from using this product, supplements do not work the same for everyone. I would be more than happy to issue you a full refund just for giving BIO X4 a fair trial. Please email me directly at so that I can ensure you receive your refund as quickly as possible. Thank you Lesley.

  5. Pat Ward says:

    I bought 1 bottle of Bio X4 about 6 weeks abo. At first, I liked it, as it made it seem easier to have bowel movements. I didn’t take 3 pills a day just 2, then toward the end just one a day. Toward the end of about 6 weeks of taking this product,my system is all messed up. I have constant gas and loose bowls. I have to run to the bathroom at least 15 – 20 times a day. I have been off the pills for over a week and its getting worse. I also have stomach cramping and headaches every day. I never had headaches before. I wish I had never started this medication. I don’t know when or if my system will ever get back to normal. Pat

  6. richard says:

    I agree that digestion is essential to good health but after reading many reviews about this product, I feel that the money spent would not achieve the desired results that this video and product promises. I’m very confused about it and have decided to continue researching this problem.

  7. blake marley says:

    This pills are great…. I take two huge bowel movements everyday. I was always having constipation problems before biox4. Its been a month ive lost ten pounds. I didn’t change my lifestyle. Iam a biox4 customer for life. The American diet is horriable …. we need all the help we can get. Thank you nucific from the bottom of my heart.

  8. Anita Reeder says:

    I have brought the bio.x4 2 90 day supplies and so that mean i have been taking them for as long as the pills last with in that time I have not seen a significant change in my weight. In fact nothing hasn’t changed my eating remains the same meaning I still crave the foods as always if I order some food from a restaurant and it’s a lot I will eat it all because my body craves it. I have written to the email and have not received any response from any one from this company asking for yous to honor what you say far as returning my money please thank you. I brought 1 bottle one month and prior to that being completed brought another I am still taking what I have left to see if anything change it has not. I paid $49 and some change for each bottle.
    I’m asking to be reimburse thank you for your time and understanding and I do understand that everything is not for everybody.

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