Bio x4 Review 2018: Ingredients, Results, Side Effects, Where To Buy It & Best Alternative

WARNING: Last Update August 2018
We do not recommend Bio x4. If you want to skip this review and go straight to the best alternative click here. Otherwise keep reading. We have some interesting stuff to share.

In this article (Last Update 2018) we will explain to you what is Nucific Bio x4, how does it work, what are its ingredients, side effects, show you real customer reviews, give you prices, where to buy it & recommend best alternative.

biox4 photo
Bio x4 is made by a company called Nucific.

It is a digestive enzyme blend that claims to use the benefits of probiotics to help lose weight quickly, as well as manage your digestive system better.

I’m going to look at Nucifix Bio x4 reviews around the Internet, plus take a look at what users say, in addition to my own personal testing, to try to get an answer the question: does Bio x4 work.

Nucifix Bio x4 Ingredients: What’s In It?

nucific bio x4 label

A great way to understand if the purported benefits of any supplements stack up is to have a look at what is in them.

So let’s take a look at the three main Bio x4 ingredients to see exactly what they do:

Digestive enzymes

According to the company who make it, Nucifix Bio x4 “contains enzymes that maximize the amount of nutrients you absorb out of everything you eat.”

These enzymes are Amylase, which is reputed to break down sugars, Lipase, which may break down fats, and Bromelain, which may help to break down proteins.

Caralluma fimbriata

Caralluma fimbriata has in many studies been shown to suppress appetite.

There is some evidence from the studies that that is indeed the case, however results were often very minor.


This is naturally found in green tea. It is reputed to boost the body’s natural ability to burn fat.

Some studies have listed great results, however these are usually disputed when the details are looked at.

Nucifix Bio x4 Side Effects

side effects

It does appear that Nucifix Bio x4 Side Effects, although common, are pretty minor.

They are generally digestive side effects that most people will suffer anyway at some stage:

  • Excessive intestinal gas
  • Bloating of the stomach
  • Minor cramps in the abdominal region
  • Nausea but not vomiting
  • Diarrhea
  • Issues with urination frequency and pain
  • Joint pain

Now obviously, anything which says it might cause you pain is a cause for concern.

However, looking around the Internet, many seemingly genuine reviews appear to say that this product eases those symptoms rather than causing them.

Certainly in my own testing of this product to see if I can replicate the positive Bio x4 results, I have experienced only a couple of the symptoms in a very minor manner.

What Results Can You Expect From Nucifix Bio x4?

how to use bio x4

The claimed results of using Bio x4 are:

  • Improved bowel regularity.
  • Better digestion.
  • Improved immune system function.
  • Positive effect on weight management.

These are of course impressive statements, and the basic rationale is that put together they support your digestive system to be more efficient and potentially to “supercharge” it in addition to suppressing appetite.

There is some clinical evidence that the ingredients do achieve what they say.

For example, users do routinely report a feeling of being less hungry.

In terms of results, I don’t think you can expect a miracle because otherwise this product would cost a fortune and be recommended by doctors all over the world.

The truth is you can’t buy Bio x4 in stores, which says a lot about the lack of confidence in this product.

So Is Nucifix Bio x4 A Scam?

No I don’t think that a Bio x4 scam is the purpose behind selling it.

Nucific make some claims around this product that sound almost too good to be true, but taken individually, the ingredients do give minor digestive benefits with some scientific evidence to back it up.

The problem comes in the marketing assumption that combining these active ingredients together forms some sort of “miracle pill” that will solve all your food problems.

I think the company gently allude to this, and then excited users have talked it up in a way that is beyond the truth.

Nucifix Bio x4 Reviews & Complaints

customers testimonials

Whenever I want to get the lowdown on how effective a diet and digestive supplement is, I always go to Amazon.

That’s a great place to get some honest positive and negative feedback from users.

Although you’ll get fake reviews, the majority are genuine, so the best place to look for a real Nucifix Bio x4 review I always find is Amazon.

I’ve had a look through all of the reviews to trying get a consensus, so let’s have a look at what people are saying.

First a typical positive review:

“I know that some of the claims are unfounded (enzymes), BUT it has really helped control my appetite. I have been taking this for a week and have stopped snacking completely because I am simply not hungry between meals. I am always hungry late at night and with this I have not snacked at all. I have not had any other changes or symptoms. I lost a pound in a week without trying.”

And a “neutral” review, which contradicts many of the positive reviews around appetite suppression and weight loss:

“I am not bloated as I used to be and I have regular bowel movements first time in my life. This is incredible! The only problem is this supplement doesn’t affect my weight or my cravings.”

What is telling for me is this negative review, which not only questions the basis of some of the more wild positive noise around the benefits of Bio x4, also notes you can buy its active ingredient separately at a far lower price:

“Please note that your body does not turn things into fat that it does not recognize, it excretes them as wastes. If you swallow a quarter, it doesn’t turn into fat, it passes out of your body as an indigested quarter. It’s the same thing with unrecognized preservatives.

Olene is also excreted as an oily substance, not turned into fat. As you’ll unfortunately find out if you eat too much. The Bio-X 4 video is full of misinformation. I am a RN and researcher and wanted to share what I saw with everyone else. Give you a heads up before you buy. You can also buy each product desperately for about $38, altogether.”

So What Are The Pros & Cons Of Nucifix Bio x4

As my own results have been quite subdued, and trying to keep a dose of reality around claims made about this product, I’m stating the Pros of Bio x4 as:

  • Natural ingredients, with no gluten or fillers.
  • 90 day money back guarantee.
  • Third-party lab tested.
  • The company is transparent about who runs it.
  • Ingredients individually do offer potential minor stated benefits.

And in terms of the cons of Bio x4:

  • You cannot buy in retail stores.
  • There are side effects although these are mostly minor.
  • There is no evidence that the combination of ingredients offers any additional benefits.
  • Some product benefits are apparently exaggerated.

Bio x4 Price & Where To Buy It

nucific official

If you are wondering where to buy Bio x4, then the first point to make is that this is not available in physical stores.

You can’t buy it unless you order online.

You can get it from specialist online retailers.

For example you can buy Bio x4 at GNC.

I’ve had a quick look and if you are interested in a purchase, you can get a Bio x4 coupon on some of the larger coupon websites, although I haven’t tested those and they change frequently.

In terms of the price, it pays to shop around.

For example prices on the official website are as follows:

  • 6 bottles (180-Day Supply): $240.00 – Save 18%
  • 3 bottles (90-Day Supply): $129.00 – Save 12%
  • 1 bottle (30-Day Supply): $49.00

Nucifix Bio x4 Review: Conclusions

In conclusion, my review of Nucifix Bio x4 has to conclude that the stated benefits of this dietary supplement are open to interpretation and challenge.

Yes the active ingredients do appear to offer some benefits, but I’m not convinced that just buying these ingredients separately at a lower price won’t have exactly the same effect, and will certainly affect your bank balance less.

I tried it myself and over the time I tried it I did feel that my digestive system was less problematic than before, but there was no sign of weight loss or a lessening of appetite.

I think an alternative supplement I would suggest is PhenQ.

It also has a natural list of ingredients, but these are radically different to those contained in Bio x4.

In addition, even if you haven’t tried PhenQ, a look around the Internet will tell you that a lot of people have and it does seem to have a much higher percentage of positive fans than a lot of these dietary supplements.

PhenQ is sold as a “fat burner”, so if that reason you have been considering Bio x4, then I strongly suggest that you spend your money on giving PhenQ ago first.

So, what do you think about our Bio x4 review? Would you buy this product or not? Share your thoughts in the comments section below!

Review Date
Reviewed Item
Bio x4
Author Rating


  1. Richard says:

    I have found this product to be beneficial. My digestive system is more efficient then before, and I do have some loss of appetite. Two weeks into using it, I give it a thumbs up!

  2. Kelly Williams says:

    I silly act disease and I wake up everyday just begging for energy cannot seem to eat anything that doesn’t make me feel bad my medicine that I take makes me feel bad and I started taking bio X4 and I just seem to have a little bit more energy I can’t digest food better and I’m not just eating anything I want I’m eating what I need to maintain a healthy diet I’m so happy I can’t say it enough if dr. Lee called me right now I would tell her thank you thank you thank you I am a very sick person but I’m not anymore thank you and I even had breast cancer and I can say that everything they gave me through all of the medicines and stuff this has made me feel better than I could ever expect better than I ever expected

    1. Brooke says:

      Did you take it while having breast cancer? One of the biggest issues I am dealing with right now, doing chemo, is that my stomach is just so screwed up. No nausea, just diarrhea. I didn’t know if you took this while doing chemo if it was more beneficial to you?

  3. Judy kramps says:

    I just saw a video on Facebook about BIO-X4. I thought I might try it, but the video never showed me how to do that . Plus-and this would be a determining factor of buying the product. The cost was 49.99 and the price would always be $49.99. So please let me know if I can buy it for that price now and in the future. Judy L K

    1. Naomi Benson says:

      Hi there Judy,

      Naomi here with Nucific. I am happy to hear that you are interested in trying our top selling product, BIO X4. I would be more than happy to assist you with your purchase. Please send me an email at so that I can further assist you with this. I look forward to hearing from you Judy. Thank you.

  4. Lesley says:

    This product caused me a lot of discomfort and the bloating was excessive. The bloating is what curbed my appetite and not what was in the product. It turned my system into a blocked and semi constipated state, not exactly what one of their claims is. It made me uncomfortable and feel ill and I had to be off of it at least a week before my system returned to normal. I messaged Dr. Amy Lee about it for feedback and the response I got, and I am not unaware that she is most likely NOT the one responding, was to call customer service about my next step. It’s been over 90 days so they are going in the trash.

    1. Naomi Benson says:

      Hi there Lesley,

      Naomi here with Nucific. I am sorry to hear that you did not have a good experience while taking BIO X4. While many of our customers see incredible results from using this product, supplements do not work the same for everyone. I would be more than happy to issue you a full refund just for giving BIO X4 a fair trial. Please email me directly at so that I can ensure you receive your refund as quickly as possible. Thank you Lesley.

    2. Deborah says:

      This is exactly what has happen

  5. Pat Ward says:

    I bought 1 bottle of Bio X4 about 6 weeks abo. At first, I liked it, as it made it seem easier to have bowel movements. I didn’t take 3 pills a day just 2, then toward the end just one a day. Toward the end of about 6 weeks of taking this product,my system is all messed up. I have constant gas and loose bowls. I have to run to the bathroom at least 15 – 20 times a day. I have been off the pills for over a week and its getting worse. I also have stomach cramping and headaches every day. I never had headaches before. I wish I had never started this medication. I don’t know when or if my system will ever get back to normal. Pat

    1. Rosanne Rogers says:

      I agree with every comment from Pat Ward. I have the same EXACT health issues

  6. richard says:

    I agree that digestion is essential to good health but after reading many reviews about this product, I feel that the money spent would not achieve the desired results that this video and product promises. I’m very confused about it and have decided to continue researching this problem.

  7. blake marley says:

    This pills are great…. I take two huge bowel movements everyday. I was always having constipation problems before biox4. Its been a month ive lost ten pounds. I didn’t change my lifestyle. Iam a biox4 customer for life. The American diet is horriable …. we need all the help we can get. Thank you nucific from the bottom of my heart.

  8. Lauren says:

    I’ve been taking Bio X4 for the past two weeks and am very happy with the product and my own change in behavior. The product recommends taking the pill five minutes before meals with water. That one step alone forces me to drink more water AND to make me more conscious about what I’m about to eat. This has helped me ask myself, “does what I’m about to it bring more energy or is it wasted?” The shift is what I believe we produce long term changes in my eating habits.
    I’ve also had less craving between meals; I don’t desire to snack all day or keep eating just to clear my plate. Furthermore, my digestion has been the best it has ever been.
    The combination of changes in attitude, drinking more water, adjusting my mindset before and during meals, better digestion, and less craving….well, I am a happy camper. I would totally recommend giving this product a try for at least a month.

  9. Debra Thomas says:

    Is Bio-x safe for coustomer with one kidney or with kidney disease .

  10. Gina O. says:

    So have a military discount?

  11. Briana says:

    Hi! I saw the video and am extremely interested. My only question is if it safe while nursing 2 times a day? Thanks

  12. Candy says:

    I haven’t read any reviews of people who have taken this for more than 6 weeks. Is Bio X4 something you take long term? Will I have to take it until my desired weight is reached? And will it work for people who have more then 100 pounds to lose? Also, I suffer from IBS. Will this aggravate it more or help it? Thank you for your time. I look forward to your response.

  13. Michelle Taylor Frazier says:

    I watched the video and would like to order the product today but it didn’t give any opportunity for it.

  14. MICHELLE DANAO says:

    Is this safe for a person with diabetes?

  15. Lori says:

    I planned on ordering 3 bottles so when I went to check it it begged me to order more or I’d never get another chance for this low price! This angered me so I’m not ordering any

    1. Shelly Bell says:

      I began using Biox4 in 2016. I ordered 6 bottles for $240. Since I discovered it works great for me if I take 1 pill, first thing in the am, every other day – I just today (2.20.18) went to the Nucific website to get a current price and it is STILL 6 bottles for $240.

  16. Karen Raimer says:

    I was hopeful that Bio- X4 would help my digestive problems but I get heartburn every time I take a pill requiring antacids and I have had watery diarrhea since starting 3 days ago. I will not be able to take them any longer. I hope I can get a refund.

  17. Sam says:

    So, the Bio X4 video recommends their pills along with eating less and healthier, regular exercise, and to give it about 1 to 2 months… PLEASE, READ ABOVE AND THINK…YOU ALL DO REALIZE WHAT MAKES YOU (OR WILL MAKE YOU) LOSE WEIGHT AND FEEL BETTER IS THE EATING LESS AND HEALTHIER, AND THE EXERCISE (HOWEVER LITTLE YOU DO), NOT THE PILLS.

  18. Monica says:

    I had my thyroid removed last year and I’m on synthyroid I started gaining weight and I’m very bloated . I decided to order a bottle today to see if it will help me.

  19. Rhonda says:

    So I started taking Bio X4 last week and since I have broke out with hives all over my body. Is there something in it that I could be allergic too. Taking that pill is the only thing I’ve done different, so that has to be it.

  20. Alfred E. Gratrix Sr says:

    I purchased your product and received it on the 23rd of January, started the suggested dosage on the 24th. of January. I have not lost one pound since this time. I quess it just doesn’t work for me and I want my money back as you quarante. Order # 288990767 consisted of 3 bottles of Bio-X4 at $89.84 and one bottle of Move 260 at $89.82 for a total of $179.66 to be returned. Please forward shipping instructions and prepaid postage ASAP.

    1. Blue says:

      LOL! You do realize this is not where you post that lol. This is just a website that decided to reciew the product.
      Also, yiu should take it for the reccomended time 1-*”2″* month’s to see results. Js

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.