Bio x4 Review 2018: Ingredients, Results, Side Effects, Where To Buy It & Best Alternative

biox4 photo


In this article (Last Update 2018) we will explain to you what is Bio x4, how does it work, what are its ingredients, side effects, show you real customer reviews, give you prices, best place to buy it & recommend best alternatives.

Bio X4 is made by a company called Nucific. It is a digestive enzyme blend that claims to use the benefits of probiotics to help lose weight quickly, as well as manage your digestive system better.

I’m going to look at Nucifix Bio x4 reviews around the Internet, plus take a look at what users say, in addition to my own personal testing, to try to get an answer the question: does Bio x4 work.


A great way to understand if the purported benefits of any supplements stack up is to have a look at what is in them. So let’s take a look at the three main Bio x4 ingredients to see exactly what they do:

  1. Digestive enzymes

According to the company who make it, Nucifix Bio x4 “contains enzymes that maximize the amount of nutrients you absorb out of everything you eat.” These enzymes are Amylase, which is reputed to break down sugars, Lipase, which may break down fats, and Bromelain, which may help to break down proteins.

  1. Caralluma fimbriata

Caralluma fimbriata has in many studies been shown to suppress appetite. There is some evidence from the studies that that is indeed the case, however results were often very minor.

  1. EGCG

This is naturally found in green tea. It is reputed to boost the body’s natural ability to burn fat. Some studies have listed great results, however these are usually disputed when the details are looked at.

Side Effects

It does appear that Nucifix Bio x4 side effects, although common, are pretty minor. They are generally digestive side effects that most people will suffer anyway at some stage:

  • Excessive intestinal gas
  • Bloating of the stomach
  • Minor cramps in the abdominal region
  • Nausea but not vomiting
  • Diarrhea
  • Issues with urination frequency and pain
  • Joint pain

Now obviously, anything which says it might cause you pain is a cause for concern. However, looking around the Internet, many seemingly genuine reviews appear to say that this product eases those symptoms rather than causing them.

Certainly in my own testing of this product to see if I can replicate the positive Bio x4 results, I have experienced only a couple of the symptoms in a very minor manner.

What Results Can You Expect?

nucific bio x4 label

The claimed results of using Bio x4 are:

  • Improved bowel regularity
  • Better digestion
  • Improved immune system function
  • Positive effect on weight management

These are of course impressive statements, and the basic rationale is that put together they support your digestive system to be more efficient and potentially to “supercharge” it in addition to suppressing appetite.

There is some clinical evidence that the ingredients do achieve what they say. For example, users do routinely report a feeling of being less hungry.

In terms of results, I don’t think you can expect a miracle because otherwise this product would cost a fortune and be recommended by doctors all over the world. The truth is you can’t buy Bio x4 in stores, which says a lot about the lack of confidence in this product.

Is It A Scam?

No I don’t think that a Bio x4 scam is the purpose behind selling it. Nucific make some claims around this product that sound almost too good to be true, but taken individually, the ingredients do give minor digestive benefits with some scientific evidence to back it up.

The problem comes in the marketing assumption that combining these active ingredients together forms some sort of “miracle pill” that will solve all your food problems. I think the company gently allude to this, and then excited users have talked it up in a way that is beyond the truth.

Nucifix Bio x4 Customer Reviews


Whenever I want to get the lowdown on how effective a diet and digestive supplement is, I always check product testimonials online. Wesbites like has a lot of Bio x4 real people reviews. Take a look below.

First a typical positive review:

“I have been using BIO X4 for over a month and have lost 11 pounds. I have tried a few other diets and have ended up on the weight roller coaster. I like that I can still enjoy the foods I love and not have to make two different meals for my family. I have noticed that I now eat less and feel full longer. I do not have the cravings for candy, chips, or ice cream. I find myself instead going for the fruits and veggies without thinking. Thank you.”

There is more 5-star customer feedbacks like this:

“I have been using BIO X4 for three months. I have lost over 35 pounds. I sleep better, eat better and my stomach problems have dissipated. I can’t believe how much energy I have. I will continue to use BIO X4. I no longer take prescription medications for my past stomach problems, fibromyalgia, diabetes or pain management. The video inspired me to change my entire way of eating and living, at age 49.”

But I have found also a negative reviews.

Hi, I’ve been taking this now for two weeks and I wake up every day with a headache and feel worse than the previous day. On top of the headache, I’m running to the bathroom constantly and have a lot of bloating and stomach pain. If this is supposed to correct my digestive system, it doesn’t seem to be working.

It’s giving more pain than pleasure and feeling the way I do makes me not want to go anywhere for fear I will have an accident.

My digestive system and head are not happy campers.”

The good thing is, company always answer to these bad reviews and try to find a solution. In this case Nucific offered a refund. Awesome!

Video Testimonial

Pros & Cons

As my own results have been quite subdued, and trying to keep a dose of reality around claims made about this product, I’m stating the pros of Bio x4 as:

  • Natural ingredients, with no gluten or fillers
  • 90 day money back guarantee
  • Third-party lab tested
  • The company is transparent about who runs it
  • Ingredients individually do offer potential minor stated benefits

And in terms of the cons of Bio x4:

  • You cannot buy in retail stores
  • There are side effects although these are mostly minor
  • There is no evidence that the combination of ingredients offers any additional benefits
  • Some product benefits are apparently exaggerated

Where To Buy It

nucific official

If you are wondering where to buy Bio x4, then the first point to make is that this is not available in physical stores. You can’t buy it unless you order online.

The best place to buy it is official website. But you can get it also from specialist online retailers like a GNC.

I’ve had a quick look and if you are interested in a purchase, you can get a Bio x4 coupon on some of the larger coupon websites, although I haven’t tested those and they change frequently.

Notice: You can buy this product on Amazon too. But these sellers are not authorized to reselling and can’t offer you a 90-day money back guarantee.

How Much Does It Cost

  • 6 bottles (180 days supply): $487.08 – SAVE %18
  • 3 bottles (90 days supply): $261.36 – SAVE %12
  • 1 bottle (30 days supply): $99.00

Final Verdict

In conclusion, my review of Nucifix Bio x4 has to conclude that the stated benefits of this dietary supplement are open to interpretation and challenge.

Yes the active ingredients do appear to offer some benefits, but I’m not convinced that just buying these ingredients separately at a lower price won’t have exactly the same effect, and will certainly affect your bank balance less.

I tried it myself and over the time I tried it I did feel that my digestive system was less problematic than before, but there was no sign of weight loss or a lessening of appetite.

Review Date
Reviewed Item
Bio x4
Author Rating

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42 thoughts on “Bio x4 Review 2018: Ingredients, Results, Side Effects, Where To Buy It & Best Alternative”

  1. Mike Cain says:

    I tried BioX4 specifically for its probiotics. I don’t remember any hard sell on the weight loss angle.
    I had almost constant Diahrea for over a year. The lab work all came back negative c-difficile etc.
    The Biox4 reps called to see how I was doing after the first 30 day. I explained that there was not a great deal of improvement. The rep. suggested taking twice the initial dose and discounted the price,
    The results have been fantastic!! I now have regular solid bowl movements!!!

  2. marion says:

    since im using BIO-X4 every time I use the bathroom when I wipe my rear end I see a little blood. is this normal

    1. Naomi Benson says:

      Marion, I’m Naomi from Nucific. Please contact your primary physician right away to ensure that Nucific Bio X4 is right for you. As with all products, we do understand that they may work well for some and not for others. If you are unable to continue taking Bio X4, I would be more than happy to issue you a refund. Just e-mail me at and I can begin the refund process! Thank you!

  3. Soila Guzman says:

    Would you accept a personal check for the purchase of BIO X 4.

    1. BirthOrderPlus says:

      Sorry Solia, we are not selling this product. We made only a review about it.

    2. Naomi Benson says:

      Hi Soila, I’m Naomi from Nucific. Please e-mail me directly at and I can assist you with purchasing the product! I look forward to hearing from you!

  4. Alysha says:

    Is the BioX4 safe to use while nursing ?

  5. Stella says:

    Hi i took Bio.X4 for one day 3 pills , The next day i woke up swollen from my head to my feet. Could this be an allergy affect? I was so tired i slept off and on all the next day after taken the 3 pills. Plus being swollen and my head started hurting i had to take my RX head medicine. I’m scared to keep taken it but i want to know if this is what happens when 1st starting? Please email me ASAP

  6. Jayne says:

    Nuficic offered me a much better price when I called with a few questions. They also answered all my questions completely.

  7. Jim Gallen says:

    I’ve been using Bio4x for almost 2 years every single day. For my wife and I, we found it to be everything advertised by Nucific. We both have lost lots of weight as well as managing my metabolism as well as changing the way we eat and live. It’s not a diet but a tool to effect the outcome. Very highly recommend. If you have only used this for a week or a month you have no idea what it can do and we have had NO side effects.

  8. Sriyanthie McCabe says:

    I used BioX4 for three months. When I stopped using it, my stomach ballooned out and has been that way ever since.

  9. Paula says:

    Are there 90 capsules to a bottle? or 30 capsules to a bottle?

  10. Martha Dreher says:

    Plz let me know if I can get a better discount, my funds are so limited. I believe bio x4 is the answer to my stomach bloating and weigh gain help.

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